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KMID : 0608520060120010059
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Korean Journal of Oriental Medicine
2006 Volume.12 No. 1 p.59 ~ p.68
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Microarray Profiles of Ligustici Rhizoma on the Pain Model of Mouse Induced by Acetic Acid
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Kim Myung-Gyou
Kim Chang-Ju
Hong Mee-Suk
Chung Joo-Ho
Boo Yung-Min
Kim Yun-Kyung
Hong Seung-Heon
Leem Kang-Hyun
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Abstract
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The present study was designed to investigate the effects of Ligustici Rhizoma on the expression of genes in the pain model induced by acetic acid. cDNA microarray (GenePlorer TwinChipTM Mouse 7.4K) was used to evaluate the gene expressions. The expressions of 32 genes were up-regulated in the Ligustici Rhizoma-treated group: they include the genes coding Casp6, Hrh3, Basp1, Sprr2h, Zfp131, Copz2, LOC432436, Itpr5, etc. The expressions of 16 genes were down-regulated in the Ligustici Rhizoma-treated group: they include the genes coding I116, Zfpm1, Cacna2d1, Xpo7, Smpd13b, Dscr1, Harp, etc. The conclusion is that the expressions of 32 genes were up-regulated and the expressions of 16 genes were down-regulated in Ligustici Rhizoma-treated group.
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KEYWORD
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Ligustici Rhizoma, cDNA microarray, gene expression
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